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Urology Research

Study Title:  A 24-month, Single Center, Pilot, Open Label, Randomized, Controlled Trial to Evaluate the Efficacy and Safety of Calcineurin-inhibitor Elimination or Reduction With Randomization at 3 Months to Everolimus/Myfortic® Versus Reduced Dose Tacrolimus/Everolimus in Adult Renal Transplant Recipients Following Campath® Induction and Steroid Avoidance (Identifier: NCT01935128)

Study Purpose:  The purpose of this study is to evaluate whether conversion to everolimus (Zortress®), allowing the elimination or reduction of calcineurin inhibitors, will reduce nephrotoxicity (measured by increased creatinine clearance) and lengthen overall graft (kidney transplant) survival (measured by 2-3 year graft survival).

Principal Investigator: Michael Rees, M.D., Ph.D.

Study Coordinator: Lisa Twining, BS for more information, please contact 419.383.6068


Study Title:  Interstitial Cystitis: Elucidation of the Psychophysiologic and Autonomic (Identifier: NCT01616992)

Study Purpose:  Interstitial cystitis/painful bladder syndrome (IC/PBS) causes severe bladder pain and extensive disability in a large group of women int he prime of their productive lives. Extensive study of the bladder itself has uncovered many abnormalities, but the investigators do not know if these are the cause or result of the disorder. None of these has led to any real long-term progress in treatment, so far. The investigators have found that other autonomic disorders often occur in both the patients themselves and in the family members of patients with IC/PBS. The investigators therefore propose to determine whether the main abnormality in IC/PBS actually lies in the autonomic nervous system, rather than the bladder. The investigators will do this through careful measurements of autonomic function and sensation in patients who have IC/PBS, both at rest, and under controlled psychological stress. The investigators will compare their measurements to patients with myofascial pelvic pain, to know which abnormalities are truly linked to IC/PBS, and which simply reflect the presence of pelvic pain.

Principal Investigator: Ajay Singla, M.D.

For more information, please contact 419-383-3578.

Last Updated: 6/17/14