Epilepsy Research Studies
Study Title: A Double-blind, Randomized, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Adjunctive Perampanel in Primary Generalized Tonic Clonic Seizures.
Study Purpose: This study is designed to evaluate the efficacy, safety, and pharmacokinetics (PK) of perampanel on Primary Generalized Tonic Clonic (PGTC) seizure frequency in adolescents and adults maintained on one to two stable antiepileptic drugs.
Principal Investigator: Imran Ali, M.D.
Study Coordinator: Shekhar Raj, for more information, please contact 419-383-4293.
Study Title: A Multicenter, Open-Label Extension Trial To Assess The Long-Term Use Of Lacosamide Monotherapy And Safety Of Lacosamide Monotherapy And Adjunctive Therapy In Subjects With Partial-Onset Seizures.
Study Purpose: This open-label extension trial will assess the long-term use of Lacosamide monotherapy and safety of Lacosamide monotherapy and adjunctive therapy in subjects with partial-onset seizures who were previously enrolled in the conversion to monotherapy trial (SP904).
Principal Investigator: Imran Ali, M.D.
Study Coordinator: Shekhar Raj, for more information, please contact 419-383-4293.
Study Title: Double-Blind, Randomized, Historical Control Study of the Safety and Efficacy of Eslicarbazepine Acetate Monotherapy in Subjects With Partial Epilepsy Not Well Controlled by Current Antiepileptic Drugs
Study Purpose: This is an 18-week, double-blind, multicenter study with gradual conversion from previous antiepileptic therapy to eslicarbazepine acetate monotherapy in subjects with partial epilepsy.
Principal Investigator: Imran Ali, M.D.
Study Coordinator: Shekhar Raj, for more information, please contact 419-383-4293.
Study Title: Long Term Eslicarbazepine Acetate Extension Study
Study Purpose: This is a long term, open-label, safety extension study in subjects with partial onset seizures.
Principal Investigator: Imran Ali, M.D.
Study Coordinator: Shekhar Raj, for more information, please call 419-383-4293
Study Title: A Randomized, Double-blind, Placebo-controlled, Multicenter, Parallel-group Study to Evaluate the Efficacy and Safety of Brivaracetam in Subjects (≥16 to 80 Years Old) With Partial Onset Seizures
Study Purpose: This study will evaluate the efficacy and safety of brivaracetam at doses of 100 and 200mg/day compared to placebo as adjunctive treatment in adult focal epilepsy subjects with partial onset seizures not fully controlled despite current treatment with 1 or 2 concomitant antiepileptic drugs
Principal Investigator: Imran Ali, M.D.
Study Coordinator: Shekhar Raj, for more information, please call 419-383-4293
Study Title: A Phase 2 Multicenter, Double-Blind, Randomized, Adjunctive Placebo Controlled Trial to Evaluate the Efficacy and Safety of YKP3089 in Subjects With Treatment Resistant Partial Onset Seizures
Study Purpose: This study is to evaluate the efficacy of YKP3089 in reducing seizure frequency when compared to baseline in subjects with partial onset seizures not fully controlled despite their treatment with 1 to 3 concomitant anti-epileptic drugs.
Principal Investigator: Imran Ali, M.D.
Study Coordinator: Shekhar Raj, for more information, please call 419-383-4293